DJI Matrice 400 vs M350 RTK: Full Comparison of DJI’s Top Enterprise Drones

Are you looking to upgrade your enterprise drone fleet in 2025? DJI has launched the Matrice 400 (M400), a powerful successor to its Matrice series designed for advanced industrial missions. But how does it compare to the tried-and-tested DJI M350 RTK?

This in-depth comparison breaks down the key differences between the Matrice 400 and M350 RTK, including flight performance, payload capacity, intelligent features, and use cases—so you can decide which drone fits your mission requirements.

Flight Time and Performance

DJI Matrice 400:
– Max flight time: Up to 59 minutes (with Zenmuse H30T)
– Max speed: 25 m/s
– More efficient with heavier payloads
– Supports advanced terrain-following and long-endurance missions

DJI M350 RTK:
– Max flight time: Up to 55 minutes
– Max speed: 23 m/s
– Reliable performance for standard surveying and inspection jobs

Verdict: M400 offers better flight endurance and speed, especially under heavier loads.

Payload Capacity and Mounting

Matrice 400 Highlights:
– Supports up to 6 kg of payload
– Can mount up to 7 payloads simultaneously
– Four E-Port V2 interfaces allow top, bottom, and front payload configurations
– Compatible with next-gen payloads like Zenmuse H30 series

M350 RTK Highlights:
– Max payload: 2.7 kg
– Compatible with Zenmuse H20, L1, P1
– Can carry up to 3 payloads (bottom/top/multi-gimbal)

Verdict: M400 is ideal for complex multi-sensor missions and heavy-lift applications.

Smart Features and Autonomy

M400 Smart Capabilities:
– AI object recognition: people, vehicles, vessels
– Smart 3D Capture and spline-based route planning
– Real-time AR overlays
– Ship auto-landing and terrain-following
– Built for BVLOS and maritime operations

M350 RTK Smart Capabilities:
– Waypoints, Smart Oblique Capture, Terrain Follow
– Compatible with DJI Pilot 2 but lacks AR and AI-driven autonomy

Verdict: The M400 is a clear winner in smart automation and advanced AI features.

Obstacle Avoidance and Safety

M400 Safety Systems:
– 360° LiDAR sensor
– mmWave radar
– Full-colour fisheye vision sensors
– Precise obstacle detection in complex environments

M350 RTK Safety Systems:
– Six-direction vision and infrared sensors
– Reliable for standard operations but less advanced than M400

Verdict: M400 offers the most advanced safety tech DJI has ever released in a drone.

Transmission and Range

M400 Transmission (O4 Enterprise Enhanced):
– Range: Up to 20 km (CE) / 40 km (FCC)
– Airborne relay support
– Dual 4G cellular dongle compatibility
– More robust signal in complex terrain

M350 RTK Transmission (O3 Enterprise):
– Range: Up to 8 km (CE) / 20 km (FCC)
– Single dongle supported

Verdict: M400 provides extended range and more reliable BVLOS support.

Build and Battery System

Feature	DJI Matrice 400	DJI M350 RTK
Weight (no payload)	~9.7 kg	~6.5 kg
Battery type	TB100 (hot-swap, fast charge)	TB65
Tethering support	Yes (native)	No
IP rating	IP55	IP55

Verdict: M400 is heavier but more versatile, with tethering support and new TB100 batteries.

Final Verdict: Should You Upgrade?

Choose the DJI Matrice 400 if you:
✔ Need high-payload flexibility (up to 6 kg)
✔ Operate in demanding environments (urban, maritime, BVLOS)
✔ Want the latest AI and autonomy features
✔ Run missions requiring multiple simultaneous sensors

Stick with the DJI M350 RTK if you:
✔ Already own compatible legacy payloads
✔ Focus on standard mapping, inspections, or public safety
✔ Need a lighter, proven drone with good performance
✔ Have budget constraints

Conclusion: DJI’s Most Capable Drone Yet

The DJI Matrice 400 is a game-changer for industries like utilities, telecom, public safety, and maritime operations. Its improved flight time, payload versatility, obstacle sensing, and smart AI make it the most capable DJI drone to date. However, for smaller teams or existing M300/M350 users, the M350 RTK remains a strong contender—especially if your current payloads and workflows already fit.